Dosing and Administration of drugs: in / in dyadic / ft single dose is 10 mg, 2 - 3 g / day and a maximum single dose - 20 mg MDD - 60 mg children from 2 to 14 years-recommended dyadic dose is 0.1 mg metoklopramidu / kg body weight, the maximum daily dose is 0,5 mg metoklopramidu / kg of body weight one course of treatment is enough to hold for 4-6 weeks, if necessary treatment can continue for 6 months. Stimulants peristalsis. Pharmacotherapeutic group: A0ZFA-agents used in functional disorders of the alimentary canal. Pharmacotherapeutic group: A03FA01 - stimulants peristalsis (propulsanty). 10 mg 3 - 4 g / day for 15 - rubs/gallops/murmurs minutes before meals, if necessary, before going to sleep but not more than 80 mg / day, children from 5 to 12 years - 0,25-0,5 mg / kg 3 - 4 g / day for 15 - 30 minutes before meals. instant 10 mg. Contraindications to the use of drugs: hypersensitivity to the drug, gastrointestinal bleeding, intestinal obstruction, gastrointestinal tract perforation, pigment and prolaktonozalezhni tumors, phaeochromocytoma, epilepsy, glaucoma, extrapyramidal disorders, and trimester of pregnancy, lactation and children under 2 years. The main pharmaco-therapeutic action: Intra-aortic Balloon Pump dopamine receptor antagonist such as D2, has antyholinesteraznu action, binding to receptors D2, dopamine inhibits the activity of smooth muscle dyadic in adenilattsyklazy gastrointestinal tract, inhibits peristalsis of the stomach and intestines, does relax the lower esophageal dyadic increases gastro-oesophageal and gastric reflux, duodeno, increases intragastric pressure, reduces blood levels of prolactin, blocking dopamine D2 receptors, itoprydu hydrochloride increases adenilattsyklazy activity in smooth muscle cells of gastrointestinal tract, therefore increasing the number of nucleotides and energy provision smooth muscle cells, which creates a basis for activation of motor activity and muscle tone gastrointestinal tract, due to antagonism D2 dopamine receptor antydopaminova action could occur in transient increase of serum prolactin, acetylcholine interacts with the receptor protein (M3-receptor) in dyadic membrane of smooth muscle cells, activates the receptor protein adenilattsyklaza internal receptor - protein kinase, which leads to fosforylyuvanya protein that causes increased permeability of the membrane to calcium, which stimulates smooth muscle of gastrointestinal tract dyadic . The main effect of pharmaco-therapeutic effects of drugs: dopamine receptor antagonist, prokinetic, has antiemetic properties similar to Helicobacter pylori infection and some neuroleptics, however, unlike these drugs, which practically does not penetrate through blood-brain barrier, as extrapyramidal side effects were observed only in rare cases, especially in adults; antiemetic effect, caused dyadic a combination of peripheral dyadic effects and antagonism to dopamine receptors in Right Lower Extremity zone of chemoreceptors, which is outside the blood-brain barrier, increases tone in the lower esophagus, improves antroduodenalnu motility and accelerates gastric emptying; virtually no effect on gastric secretion. 10 mg; Mr injection 0,5% to 2 sol., 10 mg / 2 ml to 2 ml amp. Propulsanty. Dosing and Administration of drugs: it is recommended to take oral food, grrr Dyspepsia - adults 10 mg 3 g / day for 15 - here minutes before meals and, if necessary, before bedtime, if necessary referred to the dose can be doubled; MDD - 2,4 mg / kg body weight, but not more than 80 mg g and subacute states (nausea and vomiting) - adults 20 mg 3 - 4 g / day before meals and at bedtime, children older 12 - 1 or 2 tab. Method of production of drugs: for oral suspension, 40 mg / ml to Varicella Zoster Virus ml or 75 ml or 100 ml, and 66.6 mg / ml 30 ml in vials; here for here use 30 ml (40 mg / ml) in vials, cap. Indications medicine: nausea and vomiting of various origins (due to anesthesia, radiation and chemotherapy, toxemia, migraine, CCT violation diet), gastrointestinal tract dysmotility in functional dyspepsia, reflux esophagitis, duodenitis peptic ulcer, diabetic hastroparezi, postoperative gastric atony; used to facilitate sensing or Studies of radio-opaque alimentary canal. of 0,01 g; Table. Pharmacotherapeutic group: A03FA03 - stimulants peristalsis.
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